Figure 4.

Deficiency of PXR reduces DCHP-induced macrophage foam cell formation. Four-week-old male PXR^F/FLDLR^−/− and PXR^ΔMyeLDLR^−/− littermates were treated with 10 mg/kg/day of DCHP or vehicle control daily by oral gavage for 12 weeks. (A) Peritoneal macrophages were isolated and stained with Oil Red O and hematoxylin (scale bars = 100 µm), (B) Foam cell quantification from peritoneal macrophages in studies described in panel A. Data are represented as mean ± SEM (n = 3, ** p < 0.01, and *** p < 0.001).