Figure 7.

Ablation of PXR ameliorates DCHP-elicited lipid uptake by macrophages. Four-week-old male PXR^F/FLDLR^−/− and PXR^ΔMyeLDLR^−/− littermates were fed a low-fat diet and treated by oral gavage with 10 mg/kg body weight of DCHP or vehicle control daily for 12 weeks. (A) Peritoneal macrophages were isolated and incubated with oxLDL (200 µg/mL) for 24 h and stained with Oil Red O and hematoxylin (scale bars = 100 µm). (B) Foam cell quantification from peritoneal macrophages in studies described in panel A. Data are represented as mean ± SEM (n = 3, *** p < 0.001).