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. 2022 Apr 6;14(7):1845. doi: 10.3390/cancers14071845

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cellular parameters affecting the rate of pyruvate to lactate conversion. The scheme depicts cellular components for the uptake and conversion of pyruvate to lactate. Depicted is a cell with the intracellular spaces (shaded) representing the relative pool sizes of pyruvate and lactate (ratio approx. 1:50). Shown are intracellular concentrations of substrates and coenzymes from MCF-7 and MDA-MB-231 cells (Section 3.4) as well as K_M-values reported for LDH activity by other sources [49,50]. The K_M-values for the different monocarboxylate transporters (MCT) are as reported by [30,31,51,52,53].