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. 2022 Mar 22;11(7):1063. doi: 10.3390/cells11071063

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) OAT1 (SLC22A6) evolutionarily conserved amino acids among seven mammalian species. The position of non-synonymous substitution among seven species is indicated with grey fill. Identity with human OAT1 Pan troglodytes 97.3%, Macaca mulatta 94.7%, Sus scrofa 86.5%, Bos taurus 84.2%, Rattus norvegicus 85.9%, and Mus musculus 83.3%. (B) OAT3 (SLC22A8) evolutionarily conserved amino acids among seven mammalian species. The position of non-synonymous substitution among seven species is indicated with grey fill. Identity with human OAT3: Pan troglodytes 99.4%, Macaca mulatta 96.3%, Sus scrofa 81.7%, Bos taurus 81.7%, Rattus norvegicus 78.8%, and Mus musculus 77.5%, performed by using the UniProt Align tool [35].