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. 2022 Mar 25;11(7):1114. doi: 10.3390/cells11071114

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibition of Ca_v1.3 Ca²⁺ channels decreased spontaneous Ca²⁺ transient rate under β-adrenergic stimulation in isolated Ca_v1.2^DHP−/− SANC. Line-scan and corresponding time-course of Ca²⁺ fluorescence in dormant (A) and spontaneously firing (C) Ca_v1.2^DHP−/− SANC in Tyrode, ISO (100 nM) and ISO + Nife (3 µM) conditions. Average Ca²⁺ transient rate, mean coefficient of variation and mean diastolic calcium in dormant ((B), blue, n = 16) and firing ((D), red, n = 11) Ca_v1.2^DHP−/− SANC. * p < 0.05, ** p < 0.01, *** p < 0.001 by parametric one-way ANOVA or non-parametric Friedman test.