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. 2022 Mar 23;11(7):1076. doi: 10.3390/cells11071076

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effect of stevioside on the expression of the adipogenic and fatty acid oxidation related genes in mouse epididymal adipose tissue of C57BL/6 mice and db/db mice. (a) peroxisome proliferator-activated receptor gamma (PPARγ), (b) sterol regulatory element-binding transcription factor-1c (SREBP-1c), (c) CCAAT/enhancer-binding protein alpha (C/EBPα), (d) fatty acid synthase (FAS), (e) carnitine palmitoyltransferase 1 (CPT1), (f) silent mating type information regulation 2 homolog 1 (SIRT1) (g) peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) were normalized with β-actin. C57BL/6 (C1 and C2); negative control group that received saline, db/db (D1 and D2); control group that received saline, db/db_SS (S1 and S2); control group that received 40 mg/kg of stevioside. All data are presented as mean ± SD and tests were performed in three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001.