TABLE 4.
Plasma itraconazole and hydroxyitraconazole concentrations
| Time (n) | Itraconazole
|
Hydroxyitraconazole median concn; ng/ml (minimum; maximum) | |
|---|---|---|---|
| Median concn; ng/ml (minimum; maximum) | Concn in plasma >250 ng/ml (% of total) | ||
| After 1 wk (122) | 472 (NQa; 2,359) | 77.0 | 1,136 (NQ; 2,708) |
| After 2 wk (88) | 690 (NQ; 2,236) | 84.1 | 1,411 (NQ; 3,488) |
| After 3 wk (55) | 961 (59; 3,069) | 87.3 | 1,694 (NQ; 4,108) |
| After 4 wk (30) | 1,225 (NQ; 3,460) | 86.7 | 2,018 (NQ; 4,207) |
| After >4 wk (25) | 1,957 (193; 5,165) | 96.0 | 2,677 (695; 6,762) |
a
NQ, not quantifiable.