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. 2022 Mar 29;11(7):1149. doi: 10.3390/cells11071149

Figure 2.

Figure 2

Role and regulatory mechanism of lncRNAs in cervical carcinogenesis. lncRNAs can regulate gene expression networks via regulating microRNAs, histone modifications, DNA methylation dynamics and others, resulting in altering the key pathways and oncogenes/tumor suppressor genes triggering the pathogenesis of cervical carcinogenesis. In addition, aberrant expression of lncRNAs in cervical cancer is modulated by epitranscriptional, epigenetic, and other mechanisms.