Table 1.
Role and mechanisms of lncRNAs in cervical cancer (Papers published Since March 2021).
| LncRNA | Biological Samples | Interaction with RNA | Targets/Pathway | Biological Processes | Publication Time | Ref. |
|---|---|---|---|---|---|---|
| AC010198.2 | Cells | miR-34b-3p | STC2 | Drug resistance | Oct. 2021 | [103] |
| AFAP1-AS1 | Cells | miR-27b-3p | VEGF-C | stemness | July 2021 | [104] |
| AL592284.1 | Cells and tissues | miR-30a-5p | Vimentin/EMT | proliferation, metastasis | Nov. 2021 | [105] |
| ALOX12-AS1 | Tissues | miR-3171 | NA | proliferation | Jan. 2022 | [106] |
| ANXA2P2 | Cells and tissues | miR-361-3p | SOX9 | cisplatin-resistant | Jan. 2022 | [107] |
| CASC9-1 | Cells | miR-383-5p | MAPKAP1 | proliferation, migration, invasion, apoptosis | Nov. 2021 | [108] |
| CCAT2 | Cells and tissues | miR-493-5p | CREB1 | proliferation, EMT, tumor growth | Dec. 2021 | [109] |
| DANCR | Cells and tissues | miR-145-3p | ZEB1 | tumor growth, metastasis | July 2021 | [110] |
| DARS-AS1 | Cells and tissues | NA | ATP1B2, cGMP-PKG | proliferation, invasion, migration | June 2021 | [111] |
| DLEU2 | Cells | NA | ZFP36, p53, notch signaling, p53 | proliferation, cell cycle | May 2021 | [112] |
| DUXAP8 | Cells | miR-1297 | RCN2 | malignancy, tumor growth | Nov. 2021 | [113] |
| EGFR-AS1 | Cells | miR-2355-5p | ACTN4-mediated Wnt | proliferation, migration, invasion, apoptosis | Jan. 2022 | [38] |
| FBX19-AS1 | Cells | miR-193a-5p | COL1A1 | proliferation, migration, invasion, EMT, apoptosis, metastasis | Aug. 2021 | [114] |
| FEZF1-AS1 | Cells and tissues | miR-1254 | NA | proliferation, migration, invasion | July 2021 | [115] |
| FEZF1-AS1 | Cells | miR-367-3p | SLS12AS | proliferation, migration, invasion, apoptosis | Jan. 2022 | [115] |
| FGD5-AS1 | Cells | miR-129-5p | BST2 | macrophage M1 polarization | Oct. 2021 | [116] |
| FOXD2-AS1 | Cells and tissues | NA | METTL3, LSD1/p21 | proliferation, migration, tumor growth | July 2021 | [102] |
| FOXD3-AS1 | Cells and tissues | miR-128-3p | LIMK1 | proliferation, migration, invasion | May 2021 | [117] |
| HAND2-AS1 | Tissues | miR-21-5p | TIMP3/VEGFA | proliferation, migration, invasion, apoptosis, tumor growth | June 2021 | [118] |
| HNRNPU-AS1 | Cells and tissues | miR-205-5p | AXIN2, Wnt | proliferation, apoptosis, tumor growth | Sep. 2021 | [40] |
| HOTAIR | Cells and tissues | NA | Wnt | drug resistance | Oct. 2021 | [119] |
| HOTAIR | Cells | miR-29b | PTEN/PI3K | proliferation, drug resistance, EMT | Sep. 2021 | [120] |
| HOTAIR | Stem cells | miR-203 | ZEB1 | EMT | Sep. 2021 | [121] |
| HOTAIR | Cells | miR-214-3p | NA | proliferation, apoptosis | July 2021 | [122] |
| HOTAIR HOXA-AS2 |
Cells and tissues | miR-509-3p | BTN3A1 | proliferation, migration, invasion, tumor growth | Sep. 2021 | [123] |
| HOXC13-AS | Cells, and tissues | NA | FTO, Wnt, FZD | proliferation, invasion, EMT | July 2021 | [124] |
| HOXC-AS3 | Cells and tissues | miR-105-5p | SOS1 | proliferation, migration, invasion, apoptosis | Oct. 2021 | [125] |
| HOXD-AS1 | Cells | NA | FRRS1 | proliferation, apoptosis, tumor growth | Jan. 2022 | [126] |
| ILF3-AS1 | Cells and tissues | miR-454-3p | PTEN | survival rate, migration, apoptosis, EMT | Aug. 2021 | [127] |
| KCNQ1OT1 | Cells | miR-1270 | LOXL2, PI3K/Akt | viability, apoptosis | Feb. 2022 | [67] |
| KCNQ1OT1 | Cells and tissues | miR-296-5p | HYOU1 | proliferation, migration, invasion, tumor growth | Dec. 2021 | [128] |
| LIN01006 | Cells and tissues | miR-28-5p | PAK2 | proliferation, migration, invasion, tumor growth | April 2021 | [129] |
| LINC00313 | Cells and tissues | miR-4677-3p | CDK6 | migration, EMT | Mar. 2021 | [130] |
| LINC00514 | Cells and tissues | miR-708-5p | HOXB3 | Proliferation, invasion | Jan. 2022 | [131] |
| LINC00662 | Cells | miR-103a | PDK4 | proliferation, apoptosis | June 2021 | [132] |
| LINC00665 | Cells | NA | CTNNB1, Wnt signaling | proliferation, migration, invasion, EMT | April 2021 | [41] |
| LINC00673 | Cells and serum | NA | cell cycle, p53 pathway | proliferation, cell cycle, tumor growth | May 2021 | [133] |
| LINC00707 | Cells and tissues | miR-382-5p | VEGFA | proliferation, tumor growth | June 2021 | [134] |
| LINC00885 | Cells and tissues | miR-3150b-3p | BAZ2A | Proliferation, apoptosis, tumor growth | Jan. 2022 | [101] |
| LINC00885 | Cells and tissues | NA | NA | proliferation, invasion, EMT | June 2021 | [135] |
| LINC00899 | Cells and tissues | miR-944 | ESR1 | proliferation, migration, invasion | June 2021 | [136] |
| LINC00997 | Cells | miR-574-3p | CUL2, MAPK | proliferation, migration, invasion, autophagy | July 2021 | [44] |
| LINC01133 | Cells and tissues | miR-30a-5p | FOXD1 | proliferation, metastasis, apoptosis | June 2021 | [137] |
| LNMAS | Tissues | NA | TWIST, STC1 | metastasis, EMT, immune evasion | Feb. 2022 | [138] |
| LOXL1-AS1 | Cells and tissues | miR-423-5p | ENC1, MEK/ERK pathway | proliferation, migration, invasion, angiogenesis, tumor growth | Jan. 2022 | [43] |
| MAG12-AS3 | Tissues | miR-15b | CCNE1 | proliferation, invasion | Jan. 2022 | [139] |
| MALAT1 | Cells and tissues | NA | NA | proliferation, invasion, migration | Aug. 2021 | [140] |
| MALAT1 | Cells | miR-485-5p | MAT2A | proliferation | Nov. 2021 | [141] |
| MALAT1 | Cells and tissues | miR-124-5p | NA | proliferation, tumor growth | Nov. 2021 | [142] |
| MEF2C-AS1 | Cells and tissues | miR-592 | RSPO1 | proliferation, migration, invasion | June 2021 | [143] |
| MEG3 | Cells and tissues | miR-7-5p | STC1 | ERs-mediated apoptosis | May 2021 | [144] |
| MiIR503HG | Cells and tissues | miR-191 | CEBPB | proliferation, metastasis, apoptosis | April 2021 | [145] |
| NEAT1 | Cells and tissues | miR-377 | FGFR1 | proliferation, migration, apoptosis | Jan. 2022 | [146] |
| NEAT1 | Cells and tissues | miR-34a | LDHA | drug-resistant, glycolysis rate | July 2021 | [147] |
| OIP5-AS1 | Cells and tissues | miR-124-5p | IDH2/HIF1a | proliferation, Hypoxia, Warburg effect | Aug. 2021 | [73] |
| OIP5-AS1 | Cells and tissues | MiR-147a | IGF1R, E-cadherin | migration, invasion, EMT | Mar. 2022 | [148] |
| OTUD6B-AS1 | Cells | miR-206 | cyclinD2 | drug-resistant | Oct. 2021 | [149] |
| RPL34-AS1 | Cells | NA | RPL34 | proliferation, migration, invasion, | May 2021 | [85] |
| SNHG15 | Cells and tissues | miR-4735-39 | HIF1a | tumor progression | Jan. 2022 | [72] |
| SNHG17 | Serum | miR-375-3p | NA | proliferation, migration, invasion | June 2021 | [150] |
| SNHG3 | Cells and tissues | NA | YAP1 | proliferation, migration, invasion, tumor growth | Jan. 2022 | [56] |
| SNHG5 | Cells and tissues | miR-132 | SOX4 | proliferation, migration, invasion | Mar. 2021 | [151] |
| SNHG6 | Cells and tissues | miR-485-3p | UCK2, Wnt | proliferation, migration, invasion, EMT | Nov. 2021 | [37] |
| SPINT1-AS1 | Cells and tissues | miR-214 | Wnt | proliferation, migration, invasion, tumor growth | July 2021 | [39] |
| TDRG1 | Cells and tissues | miR-214-5p | SEMA4C | invasion, tumor growth, hypoxia-induced glycolysis | April 2021 | [74] |
| UCA1 | Cells and tissues | miR-299-3p | NA | proliferation, invasion | Nov. 2021 | [152] |
| UNC5B-AS1 | Cells and tissues | miR-4455 | RSPO4 | proliferation, migration, invasion, apoptosis | Dec. 2021 | [153] |
| USP30-AS1 | Cells and tissues | miR-299-3p | PTP4A1 | proliferation, migration, invasion, tumor growth | July 2021 | [154] |
| WT1-AS | Cells and tissues | NA | SPL1/PIK3AP1 | proliferation, autophagy, apoptosis, tumor progression | July 2021 | [155] |
| WTA-AS | Cells and tissues | miR-205 | NA | cell cycle, apoptosis, migration, invasion, EMT, tumor growth | Dec. 2021 | [156] |
| ZFAS1 | Cells | MiR-190a-3p | KLF6 | proliferation, invasion, migration | Feb. 2022 | [100] |
Note: NA: not available.