Figure 4.

In vivo distribution of boron delivered by TMZB and BPA (50 mg ¹⁰B/kg). Mice were treated with TMZB or BPA for various lengths of time. Boron concentrations in the heart, lung, liver, spleen, kidney, and tumor were analyzed using ICP-AES. (a) Boron concentrations in the heart, lung, liver, spleen, kidney, and tumor after TMZB or BPA injection for 2 h. (b) Tumor/blood ratio after TMZB or BPA injection for 1, 2, 4, or 6 h. (c) Tumor/normal tissue ratio after TMZB or BPA injection for 1, 2, 4, or 6 h. Mean values with standard error are shown. Statistical comparisons were carried out with a paired t-test. * p < 0.05, ** p < 0.01.