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. 2022 Apr 1;11(7):1030. doi: 10.3390/foods11071030

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulatory mechanism of GLPP on hyperlipidaemia, hypercholesterolemia, and gut microbiota dysbiosis in rats fed on HFD. GLPP: Ganoderma lucidum polysaccharide peptide; HFD: high-fat diet; TG: triglyceride; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; FFA: free fatty acids; SCFA: short-chain fatty acids; OSTα: organic solute transporter alpha; CYP7A1: cholesterol 7α-hydroxylase; SREBP-1C: sterol regulatory element-binding protein-1C; PPARα: peroxisome proliferator-activated receptor alpha; HMG-Coa: 3-hydroxy-3-methylglutaryl coenzyme A; BSEP: bile salt export pump; MRP3: multidrug-resistance-associated protein 3; OATP2: organic-anion-transporting polypeptides 2. Source: Reprinted with permission from Lv et al. [226]. 2022, Elsevier.