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Application of artificial super-oocytes for patient-specific stem cells and infertility treatment. Oocytes can be obtained from pluripotent stem cells, and after enucleating, can be used either for spindle transfer (ST) for mitochondrial replacement therapy (MRT), transfer of the somatic cell nucleus (SCNT) from the patient’s cells for embryonic stem cell (ESC) culture, or nuclear transfer-derived ESCs (NT-ESCs) for fertility treatment and generation of the new oocytes.
