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. 2022 Mar 25;19(7):3919. doi: 10.3390/ijerph19073919

Table 3.

Selected cases of aseptic meningitis and head and neck involvement from literature.

Authors/Year Etiology Previous Signs and Symptoms AM Signs and Symptoms at Presentation Head and Neck Involvement
Gritti et al., 2011 [10] Behçet’s disease RAS, genital ulceration Fever, headache, pain and stiffness of the neck, impaired vision of the left eye Headache,
neck pain
Kikuchi et al., 2010 [18] Behçet’s disease RAS Headache, fever, RAS RAS, headache
Mullins et al., 2009 [11] Behçet’s disease RAS, recurrent knee synovitis Headache, confusion, chest pain, fever, drowsiness, RAS, skin rash RAS, headache
Starr and Smith, 2017 [19] Behçet’s disease Data not available Fever, malaise, photophobia, phonophobia, headache, nausea, vomiting, neck stiffness, RAS, genital ulcers RAS, headache, neck stiffness
Kara et al., 2006 [21] Behçet’s disease Growth retardation,
arthralgia, scrotal ulcers, nodular
dermal lesions, RAS
Headache, fever, vomiting, RAS, bilateral vitritis, papilledema, retinal hemorrhage RAS, headache
Sakakibara et al., 2009 [23] Behçet’s disease None Headache, fever, vomiting, neck stiffness, RAS, genital ulcers RAS, headache
Alkan et al., 2019 [14] Behçet’s disease RAS, arthritis Headache, diplopia, papilledema Headache
Bir et al., 2005 [24] Behçet’s disease RAS, genital ulceration Headache, papilledema, neck stiffness, venous sinus thrombosis,
intracranial hypertension
Headache, intracranial hypertension
Rossi and Saddi, 2006 [26] Sjögren syndrome SICCA syndrome Headache, pain, and stiffness of
the neck, diplopia
Lymphocytic infiltration pattern at minor salivary glands biopsy, headache, neck stiffness
Akiyama et al., 2020 [28] Sjögren syndrome Case report 1: recurrent AM Case report 1: fever, headache, sore throat Case report 1: lymphocytic infiltration pattern at minor salivary glands biopsy, headache
Case report 2:
xerophthalmia
Case report 2: headache, fever,
vomiting, polyarthralgia
Case report 2:
lymphocytic infiltration pattern at minor salivary glands biopsy, headache
Basheer et al., 2019 [27] Sjögren syndrome SICCA syndrome, arthralgia, fatigue Headache, photophobia,
vomiting, neck and
shoulder pain
Headache, neck pain.
Ishida et al., 2007
[33]
Sjögren syndrome Recurrent AM Headache, nausea, fever, neck stiffness Lymphocytic infiltration pattern at minor salivary glands biopsy, headache
Ozasa et al., 2020
[30]
Sjögren syndrome and mixed connective tissue disease Bilateral pain and numbness in the maxillary anterior gingiva and eyelids,
generalized body pain
Headache, fever Trigeminal neuropathy, headache.
Zhao et al., 2020
[31]
Sjögren syndrome Arthritis, glucosuria Headache, fever, nausea, vomiting Lymphocytic infiltration pattern at minor salivary glands biopsy, headache
Alfaro-Giner et al., 1992
[32]
Sjögren syndrome and mixed connective tissue disease Trigeminal neuropathy Fever Facial pain and hypoesthesia, SICCA syndrome
Ventura et al., 2013 [46] IVIg-induced in pemphigus vulgaris patient Cutaneous and mucosal bullae Headache, neck stiffness, photophobia,
nausea
Oral mucosal blisters

Legends: RAS: Recurrent aphthous stomatitis.