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. 2022 Mar 22;11(7):1071. doi: 10.3390/cells11071071

Figure 4.

Figure 4

LPA5 regulates LPA-induced secretion of cyto-/chemokines in primary microglia. Wt and LPA5-/- cells were treated in the absence (C) or presence of LPA (1 µM) for the indicated times. Supernatants were collected and (A–C) cytokine (TNFα, IL-6, and IL-1β) and (D–F) chemokine (CXCL10, CXCL2, and CCL5) concentrations were quantified by ELISA. Values are expressed as mean ± SEM of five independent experiments. * p < 0.05, ** p < 0.01 compared to wt control; # p < 0.05, ## p < 0.01 for LPA5-/- compared to wt cells (two-way ANOVA with Bonferroni correction).