Table 1.

Enrolment, assessments and interventions according to SPIRIT guidelines.

Time Point	t−1	T0 Baseline Evaluations			T1 10 Weeks
		Visit 1	Visit 2	Visit 3	Visit 4, 5, 6
Enrolment:
Eligibility screening	X
Informed consent	X
Assessments:
Medical visit		X			X
Blood draw 1		X			X
Body-composition analysis		X			X
Spirometry		X			X
$\dot{V}$O2max		X			X
Neuropsychological assessment 2			X		X
NIRS pulsatility, neurovascular coupling				X	X
5 Sit-to-Stand test				X	X
Timed Up-and-Go test				X	X
6 min walking test				X	X
Self-reported questionnaires 3				X	X
Interventions:
control group				Have to maintain their daily habit
cardiopulmonary-exercise-training group				8 weeks; 3 times/week

¹ complete blood count, PTT (thromboplastin time), Fibrinogen (factor I in g/L), PT (prothrombin level, in sec and in %), INR (international normalised ratio), C-reactive protein, TNF alpha, IL-6, IL-1, IL-10, lactate dehydrogenase (LDH), Uric acid, Albumin, Myeloperoxidase (MPO). ² remote version of the Montreal Cognitive Assessment (MoCA), Hopkins Verbal Learning Test (verbal memory), Digit Span (short-term memory and oral-memory version of the Trail-Making Test (executive functions), phonological and semantic verbal-fluency test (language and executive functions). ³ SF-36 (quality of life), stress (State-Trait Anxiety-Inventory questionnaire, Perceived-Stress Scale questionnaire), sleep quality (Pittsburgh Sleep-Quality Index questionnaire) and long-COVID-19 symptoms questionnaire.