Figure 4.

2-APB suppresses the store-operated Ca²⁺ entry and abrogates the second (delayed) phase of Yoda1-induced Ca²⁺ increase in eMSCs. (A) Shown are typical Ca²⁺ responses from the representative experiment (n = 4) following the 1 μM and 5 μM 2-APB application on eMSCs. Measurements were performed in individual cells with the imaging system. [Ca²⁺]_i is plotted versus time. Each point is a mean ± SD from 17 cells. (B) 2-APB suppresses both SOCE and the delayed phase of Piezo-mediated Ca²⁺ entry in eMSCs. Each point is a mean ± SD from 13 cells.