Table 2.

Cell culture studies included in the systematic review.

No.	Cell Type	Study Endpoint	IL-22 Role
4 [14]	Cultured human colon adenocarcinoma cells	The potential role of IL-20, IL-22, and IL-24 in colonic epithelial renewal	IL-22 induces cell proliferation in highly proliferative cells, such as intestinal epithelial cells.
11 [21]	Cultured keratinocytes	The function of mononuclear cells in the re-epithelialization process of diabetic wounds	High-glucose cultivation reduced the IL-22 production in mononuclear cells, hampering the migration of keratinocytes.