Table 3.
Atypical ubiquitination of mitochondrial proteins *.
| Accession (Swiss-Prot) | Gene | Description (Swiss-Prot) | Function |
|---|---|---|---|
| Q9NZ45 | CISD1 | CDGSH iron sulfur domain-containing protein 1 | Regulation of electron transport and oxidative phosphorylation |
| Q14318 | FKBP8 | Peptidyl-prolyl cis-trans isomerase FKBP8 | Apoptosis regulation, host–virus interaction |
| Q8TB36 | GDAP1 | Ganglioside-induced differentiation-associated protein 1 | Regulates the mitochondrial network by promoting mitochondrial fission |
| GPKOW | MOS2 | G-patch domain and KOW motifs-containing protein | RNA-binding protein involved in pre-mRNA splicing |
| Q13505 | MTX1 | Metaxin-1 | Transport of proteins into the mitochondrion |
| Q969V5 | MUL1 | Mitochondrial ubiquitin ligase activator of NFKB 11 | Control of mitochondrial morphology by promoting mitochondrial fragmentation |
| Q9Y3E5 | PTRH2 | Peptidyl-tRNA hydrolase 2, mitochondrial | Promotes caspase-independent apoptosis by regulating AES and TLE1 |
| Q15388 | TOMM20 | Mitochondrial import receptor subunit TOM20 homolog | Central component of the receptor complex responsible for import of protein precursors into mitochondria |
| O96008 | TOMM40 | Mitochondrial import receptor subunit TOM40 homolog | Channel-forming protein essential for import of protein precursors into mitochondria |
| O94826 | TOMM70 | Mitochondrial import receptor subunit TOM70 homolog | Recognizes and translocates mitochondrial preproteins from the cytosol into the mitochondria |
| Q9Y2W6 | TDRKH | Tudor and KH domain-containing protein | Participates in the primary piRNA biogenesis pathway |
| Q8IWA4 | MFN1 | Mitofusin-1 | Mitochondrial outer membrane GTPases that mediate mitochondrial clustering and fusion |
| O95140 | MFN2 | Mitofusin-2 | |
| P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | Isoforms of the outer membrane integral pore-forming multifunctional protein. Regulate the exchange of a variety of metabolites (including ATP and ADP), thus controlling crosstalk between mitochondria and the rest of the cell |
| P45880 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | |
| Q9Y277 | VDAC3 | Voltage-dependent anion-selective channel protein 3 | |
| Q8IXI2 | RHOT1 | Mitochondrial Rho GTPase 1 (Miro1) | Mitochondrial GTPase involved in mitochondrial trafficking |