Table 1.

The effects of chemotherapeutics utilized against PDAC in in vivo and in vitro experiments.

Drug	Origin of Exosome	Cell Line/Animal	Results	References
Paclitaxel	Mesenchymal	CFPAC-1 cells	Less than 10% greater IC50 of PTX-MV vs. PTX	[99]
GEM	Mesenchymal	CFPAC-1 cells	BM-MSCsGCB-CM has 40% less V50 than pMSCsGCB-CM	[100]
GEM	Autologous	Panc-1 cells/BALB/c nude mice	At day 16 (after treatment): ExoGEM 10 mg/kg-50% lower tumor volume	[101]
			At day 16 (after treatment): GEM 50 mg/kg-2 fold increase in tumor volume
GEM and Paclitaxel	Bone Marrow-MSC	MiaPaca-2 cells/nude mice	Survival: Exo-GEMP-PTX group: 88 days Exo group: 42 days GEM group: 60 days Exo-GEM group: 63 days GEMnab-PTX group: 73 days	[102]
Curcumin	Autologous	PANC-1 and MIA PaCa-2 cell lines	PANC-1 cells at 72 h: curcumin-positive exosomes 50% cell killing vs. curcumin-negative exosomes 0% cell killing	[103]
			MIA PaCa-2 at 72 h: curcumin-positive exosomes 60% cell killing vs. curcumin-negative exosomes 0% cell killing