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. 2022 Mar 28;23(7):3709. doi: 10.3390/ijms23073709

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ELK3 controls extracellular matrix (ECM) remodeling-related genes to control cell migration. (A) Gene set enrichment analysis of RNA sequencing data from SNU638 cells transfected with siCon or siELK3. Cell adhesion-related genes were positively enriched and cell junction disassembly-related genes were negatively enriched in SNU638 cells transfected with siELK3. (B) Pie graphs showing biological pathways in ELK3-depleted SNU638 cells. Numbers indicate the number of genes in each biological pathway. (C) Heatmap analysis of genes associated with cell migration and cell adhesion. (D) Bar graph showing the Database for Annotation, Visualization, and Integrated Discovery (DAVID) annotation of genes involved in cell migration and cell adhesion. (E) Map data of Search Tool for the Retrieval of Interacting Genes analysis (STRING). The thickness of the lines represents the confidence of the interaction.