Table 2.
Potential influencing factors on plasma PACAP-38 levels. ACEI: angiotensin-converting enzyme inhibitor, ARB: angiotensin-II receptor blocker, MRA: mineralocorticoid receptor antagonist, CRT: cardiac resynchronization therapy, ICD: implantable cardioverter-defibrillator, EF: ejection fraction, LV-EDD: left ventricular end-diastolic diameter, RV-EDD: right ventricular end-diastolic diameter, IVC: inferior vena cava size, LDL: low-density lipoprotein, HDL: high-density lipoprotein. Spearman’s correlation test was performed.
| Correlation Coefficient (r) | Significance (p) | |
|---|---|---|
| Comorbidities | ||
| Hypertension | r = −0.095 | p = 0.532 |
| Diabetes mellitus | r = 0.003 | p = 0.983 |
| Atrial fibrillation | r = 0.064 | p = 0.671 |
| Therapy | ||
| ACEI/ARB | - | - |
| β-blocker | - | - |
| MRA | r = 0.031 | p = 0.178 |
| Diuretics | r = 0.081 | p = 0.708 |
| Ivabradin | r = 0.206 | p = 0.326 |
| Digoxin | r = 0.048 | p = 0.822 |
| CRT | r = 0.005 | p = 0.973 |
| ICD | r = 0.067 | p = 0.659 |
| Echocardiographic parameters | ||
| EF (%) | r = 0.113 | p = 0.456 |
| LV-EDD (mm) | r = 0.063 | p = 0.689 |
| RV-EDD (mm) | r = −0.012 | p = 0.938 |
| Mitral regurgitation | r = 0.045 | p = 0.776 |
| Tricuspid regurgitation | r = 0.034 | p = 0.827 |
| IVC (mm) | r = 0.067 | p = 0.671 |
| Laboratory parameters | ||
| Cholesterol | r = 0.043 | p = 0.736 |
| LDL cholesterol | r = 0.183 | p = 0.474 |
| HDL cholesterol | r = 0.041 | p = 0.826 |
| Triglycerides | r = 0.033 | p = 0.354 |
| Blood urea nitrogen | r = 0.010 | p = 0.946 |
| Serum creatinine | r = 0.100 | p = 0.514 |