Table 3.

Correlation between the plasma level of different cytokines (IL-1 β, IL-2, IL-4 and IL-10) and PACAP-38 with Spearman’s correlation test or with multivariate analysis (taking also into account the type of heart failure: acute or chronic). Statistically significant differences with p-values of ** p < 0.001 and * p < 0.05 are indicated.

Cytokines	Correlation Test		Multivariate Analysis
	Correlation Coefficient (r)	Significance (p)	Correlation Coefficient (r)	Significance (p)
IL-1 β	r = 0.539 *	p = 0.002	r = 0.780 **	p < 0.001
IL-2	r = 0.494 *	p = 0.005	r = 0.812 **	p < 0.001
IL-4	r = 0.481 *	p = 0.006	r = 0.800 **	p < 0.001
IL-10	r = 0.367 *	p = 0.042	r = 0.799 **	p < 0.001