Table 5.
Examination of the correlation between the potential influencing factors and tissue PACAP-38 levels. NICM: non-ischemic cardiomyopathy, ICM: ischemic cardiomyopathy, EF: ejection fraction, LV-EDD: left ventricular end-diastolic diameter, RV-EDD: right ventricular end-diastolic diameter, LDL: low-density lipoprotein, HDL: high-density lipoprotein. Spearman’s correlation test was used to examine the correlation between NT-proBNP levels, different echocardiographic and laboratory parameters and heart tissue PACAP-38 levels. Moreover, multivariate analysis was performed, also considering the etiology of cardiomyopathy (non-ischemic or ischemic).
| Correlation Coefficient (r) | Significance (p) | |
|---|---|---|
| NT-proBNP (pg/mL) | ||
| All patients | r = −0.167 | p = 0.435 |
| NICM | r = −0.041 | p = 0.899 |
| ICM | r = −0.254 | p = 0.425 |
| with multivariate analysis | r = −0.187 | p = 0.688 |
| Echocardiographic parameters | ||
| EF (%) | r = 0.146 | p = 0.494 |
| LV-EDD (mm) | r = 0.167 | p = 0.369 |
| RV-EDD (mm) | r = −0.177 | p = 0.407 |
| Posterior wall thickness (mm) | r = 0.240 | p = 0.451 |
| septal wall thickness (mm) | r = 0.197 | p = 0.540 |
| Routine laboratory tests | ||
| Cholesterol | r = 0.068 | p = 0.751 |
| LDL cholesterol | r = 0.089 | p = 0.693 |
| HDL cholesterol | r = 0.057 | p = 0.766 |
| Triglycerides | r = 0.129 | p = 0.567 |
| Blood urea nitrogen | r = −0.031 | p = 0.887 |
| Creatinine | r = −0.122 | p = 0.578 |
| Sodium | r = −0.280 | p = 0.196 |
| Potassium | r = −0.307 | p = 0.154 |