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Mechanism of aggrephagy during the occurrence of AD. (A) Polyubiquitinated Aβ plaques and fibers binds to p62 and NBR1 specifically, and initiate degradation through aggrephagy. (B) Hsc70 interacts with CHIP to regulate tau ubiquitination and then is recruited by p62. (C) All these aggregate proteins are wrapped by autophagosomes for degradation. (D) KFERQ binds with tau aggregates and is transferred to the lysosome by the Lamp2A receptor for degradation.
