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. 2022 Mar 25;23(7):3609. doi: 10.3390/ijms23073609

Figure 2.

Figure 2

Mitophagy in the pathogenesis of AD. (A) Impairment of the mitochondria occurs in the early stages of AD, and Aβ and P-tau are increased. (B) Aβ and P-tau interact with VDAC1 and Complex IV, and interfere with mitochondrial function. (C) Aβ and P-tau induce mitochondrial fragmentation by reducing MFN1/2 and activating Drp1. (D) Hyperphosphorylation of tau blocks the binding of tau with microtubules, disrupting mitochondrial axon transport. (E) Aβ and P-tau disturb the recruitment of PINK1 and Parkin, causing mitophagy dysfunction.