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Reticulophagy in the pathogenesis of AD. (A) RTN3 aggregation counteracts the negative regulation of BACE1 activity by RTN3, causing Aβ to increase in the aging brain. (B) Deposition of Aβ inhibits the interaction of the ER and microtubules, inducing reticulophagy. (C) ER stress/AD factors increase misfolded proteins through the IRE1 and PERK pathway. (D) KFERQ binds with impaired ER for CMA degradation. (E) Autophagosomes wrap the impaired ER for degradation.
