Figure 3.

Sublingual fentanyl dosing and opioid adverse events (during the first 6 hours of monitoring) are shown diagrammatically for each treatment episode. MTD episodes are episodes 10–31. In the top section, the black bar represents the dose of SFL given for the treatment episode. In the second and third sections, the most severe degree of respiratory depression and sedation, and in the lower sections, most severe grades of pruritis, nausea and dizziness for each episode are shown as grey bars.

SLF: sublingual fentanyl (dose in micrograms); RR: respiratory rate; A: alert; V: responds to verbal commands; P: responds to painful stimuli; U: unresponsive.