Table 4.

Studies in which adverse effects caused by the use of enrofloxacin were observed.

Study Type	Animal Model	Observed Effect	Reference
in vitro	Cattle	Toxic interaction with serum albumin	[142]
	Cattle	Cytotoxicity on embryonic limb bud cells and midbrain cells	[143]
in vivo	Rats	Slight decrease in liver vitamin A and E levels	[144]
	Elephants	Anorexia, decreased water intake, constipation, depression, ataxia, limb paresis, and tremors	[145]
	Genetic Absence Epilepsy Rats from Strasbourg (GAERS)	Induction of clonic seizures	[146]
	Dogs	Alteration of cardiac ventricular depolarization and repolarization, as well as increasing the risk of ventricular arrhythmias.	[147]
	Acipenser baerii	Structural damage to liver, kidney, and cartilage	[148]
	Danio rerio	Changes in the catalytic activity of glutathione peroxidase and glutathione S-transferase	[149]