Figure 3.

The FtsWI peptidoglycan synthesizing holoenzyme. FtsI consists of a short cytoplasmic domain, a transmembrane domain (α1), a pedestal domain (including head domain) and a C-terminal transpeptidase domain. FtsW comprises a collection of 10 transmembrane domains (TM1-10) which are connected by periplasmic and cytoplasmic loops. Multiple regions that control the activity of FtsWI are indicated by the colored boxes and detailed further in Figure 3 and Figure 4. Although no crystal structure of the FtsWI is available, predictions of the structure have been produced with AlphaFold2 advanced and visualized with the PyMOL Molecular Graphics System, Version 2.5.2 Schrödinger, LLC. Sequences for the prediction were obtained from the UniProtKB database (P0ABG4-1 for FtsW and P0AD68-1 for FtsI).