Figure 7.

FtsA structure. FtsA in a cytoplasmic protein that binds to the inner membrane and acts as a membrane anchor for FtsZ. FtsA is divided into four domains which interact with different divisome components [81]. The 1A domain (green) is involved in membrane binding and has also been linked to FtsK binding (see text). The 2B domain (blue) contains a region that binds FtsZ and, together with the 1A and 2A domains, forms a nucleotide (ATP)-binding pocket at the FtsA core. The 1C domain (yellow) is involved in the recruitment of FtsN. FtsA oligomerizes through 1A–1C and 2A–2B interactions. Multiple SF mutants are shown in red, which are mostly located at the oligomerization interfaces.