Figure 13.

FtsBL coiled coil stability. Modulating the stability of the FtsBL coiled coil structure is an integral part of sPG synthesis regulation. The stability is dynamically affected by polar (Q39, R67, R74; N50) and hydrophobic (L46, L77, W81) clusters located at the inner part of the coiled coil between the transmembrane and the CCD/AWI domains. FtsB contains an alanine-rich patch at the other face of the helix, forming a dimerization/intercoil domain. The CCD (red) and AWI (green) domains just upstream are involved in the suppression and activation of sPG synthesis, respectively. Just above the FtsB CCD domain, a region stably interacting with FtsQ can be found.