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SARS-CoV-2 Mpro sequence variations based on COVID-3D database. Top20 variations: residues with more than 300 known variants (a). Mutation frequency of active-site residues involved in the binding of nirmatrelvir (b). The database was accessed at 14 January 2022. The bars are colored based on domain organization (domain I–III are blue, while the linker between domain II and III is gray).
