Figure 1.

Cell viability of HepG2 cells incubated with the agents alone and combined, for 24 h. RYR = Red Yeast Rice. From A to E the dose-response study on cell viability was measured by MTT test of each single extract such as vitamin K2 and vitamin D3 (A), quercetin and resveratrol (B), CoQ10 and folic acid (C), astaxanthin and sodium selenite (D), sage extract and RYR (E). In (F) the effects of the better concentration of single agents alone and combined (Esterlo10^®) were compared to RYR and atorvastatin alone. Viability was calculated as the reduction percentage of cells in the culture medium without the addition of test substances. Data are mean ± SD of five independent experiments performed in triplicates. * p < 0.05 vs. control.