Table 2.
Epidemiological studies on the effects of Pb on the expression of DNA repair-related genes.
| Subject | N | Blood Pb Level (µg/dL) (Mean ± SEM) |
DNA Repair Gene | Method | Result | Reference |
|---|---|---|---|---|---|---|
| Workers of construction area origin | 100 exposed 100 controls |
- | OGG1-2a | RT-PCR | Significant down-regulation | Akram et al. (2019) [35] |
| Welding, handicraft, and paint workers | 100 exposed 100 controls |
7.88 ± 1.27 1.27 ± 0.11 |
OGG1, XRCC1, XPD | RT-PCR | Significant down-regulation | Singh et al. (2020) [36] |
| Exposed residents | 40 exposed 20 controls |
2.10 ± 0.25 1.12 ± 0.06 |
OGG1, APE1 | RT-PCR | No significant change | Bakheet et al. (2013) [37] |
RT-PCR: reverse transcription-polymerase chain reaction; OGG1: 8-oxoguanine DNA glycosylase 1; APE1: AP endonuclease; XRCC1: X-ray repair cross-complementing protein 1; XPD: xeroderma pigmentosum group D.