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. 2022 Mar 22;23(7):3436. doi: 10.3390/ijms23073436

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MK-801 induces pre-pulse inhibition deficits, which are ameliorated by clozapine treatment. Effects of clozapine 5 mg/kg (Clz), MK-801 0.1 mg/kg, and their combinations on prepulse inhibition (PPI) of rats on the 1st, 8th, and 15th days of the treatments at 73 (A), 76 (B), and 82 (C) decibel (dB) prepulse intensity levels (^a p < 0.05, compared to Veh + Saline group; ^b p < 0.05, compared to Veh + MK-801 group; ^c p < 0.05, compared to Clz + Saline group, post hoc Tukey’s tests; Veh, vehicle, n = 8/group).