Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 29;23(7):3738. doi: 10.3390/ijms23073738

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of cardiolipin (CL) on physiology and apoptosis. Emphasis is given on CL’s unique ability to directly bind and anchor proteins and CytC on IMM. Formation of monolyso-CL leads to loss of all physiologic abilities of mature CL, flipping to the OMM from the IMM where CL is normally confined and facilitation of apoptosis in a Bid-mediated manner. Of note, loss of mature CL from the IMM disturbs electron transport, leading to increased ROS formation and ignition of the apoptotic cascade. Besides, mature CL loss allows for the membrane-bound CytC to be released to the IMS and sensitizes to membrane permeability and the cell to apoptosis. Created with BioRender.com, accessed on 20 March 2022.