Figure 1.
Expression of BRCA1/2 mRNA in cancer vs. normal (Oncomine and TCGA database). (a) This graphic generated by Oncomine (https://www.oncomine.org/resource/login.html, accessed on 10 February 2022) indicates the numbers of datasets with statistically significant (p < 0.01) mRNA overexpression (red) or downexpression (blue) of BRCA1/2 (different types of cancer vs. corresponding normal tissue). The threshold was designed with the following parameters: p value of 1 × 10−4, fold change of 2, and gene ranking of 10%. (b) Human BRCA1/2 expression levels in different tumor types from TCGA database were determined by TIMER 2.0 (http://timer.cistrome.org, accessed on 10 February 2022) (* p < 0.05; *** p < 0.001).