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. 2022 Mar 29;23(7):3758. doi: 10.3390/ijms23073758

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Overview of the involvement of 5-HT in physiological and pathophysiological conditions. 5-HT plays an important role in gut physiology and in maintaining intestinal homeostasis. 5-HT is also important in the regulation of immune response and angiogenesis. Alteration in 5-HT production resulting in dysregulation of 5-HT signaling is associated with various disorders like inflammatory bowel diseases, celiac disease and neuroendocrine disorders. 5-HT: 5-hydroxytryptamine. Modified from Banskota et al., 2019 [76].