Table 1.

Unsolved questions and future prospective studies in Cardio-Oncology.

Prediction of CTRCD	1. Compare Individual NETs with current standard -GLS and hsTn 2. Combination with NETs, GLS and hsTn better than GLS and hsTn?
Prediction of thrombosis Events including VTE, ACS and stroke	1. Compare circulating components of NETs with Khorana score 2. New score system with NETs to predict thrombosis events
NETs with mLDL & Atherosclerosis after Cancer Treatment	1. The causality between NETs and mLDL formation after cancer treatment 2.NETs burden after cancer treatment with atherosclerosis development
NETs Clearance with Cancer Recurrence, Metastasis and CTRCT	1. NETs clearance to prevent cancer recurrence, metastasis, and CTRCT 2. The best solution/mechanism for NETs clearance

NETs: neutrophil extracellular traps; CTRCD: cancer therapeutics-related cardiovascular dysfunction; GLS: global longitudinal strain; hsTn: high-sensitivity cardiac troponin; VTE: venous thromboembolism; ACS: acute coronary syndrome; Khorana score: a score to predict cancer VTE; mLDL: modified low-density lipoprotein; CTRCT: cancer treatment-related cardiovascular toxicity.