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. 2022 Mar 25;23(7):3591. doi: 10.3390/ijms23073591

Table 6.

Controlled release systems with active substances which are available in Melissa officinalis.

Type of Delivery System Delivery System Effect Reference
Type of Carrier Active Agent
Organic/Inorganic Nanoparticles poloxamer, soybean lecithin ethosome caffeic acid antioxidant [116]
chitosan, sodium alginate [117]
poloxamer [118]
chitosan rosmarinic acid * antioxidant [119,120]
rosmarinic acid antimicrobial [121]
PEG-containing amine anti-inflammatory [122]
glycerol monostearate, soya lecithin, hydrogenated soya phosphatidyl choline therapeutic [123]
mesoporous silica antioxidant [124]
nanostructured lipid citral anticancer [125,126]
Hydrogels chitosan citral anticancer [127]
imine-PEG-ylated chitosan local therapy [128]
Vesicles soybean phospholipids citral antimicrobial [129]
ethosome caffeic acid antioxidant [116]
soybean phosphatidyl-choline liposomes β-caryophyllene antiproliferative [130]

* from a natural extract.