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. 2022 Mar 30;23(7):3815. doi: 10.3390/ijms23073815

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Vascularization in Group 3 and SHH/TP53-mut orthotopic medulloblastomas dependent on treatment of the MB-bearing mice with radiation therapy (RT), decitabine (DEC), and/or abacavir (ABC). (a) Capillaries and larger vessels per field of view (FOV). Data presented mean ± SEM, numbers of analyzed animals/treatment group is given below. Statistical significance was determined by two-sided Mann-Whitney test (*, p ≤ 0.05 versus sham-treated control). (b) Representative photographs of CD31-stained vascular cells (capillaries and large vessel) in Group 3 and SHH/TP53-mut tumors, scale bars = 100 µm. (c) CD31 and VEGF mRNA expression in Group 3 medulloblastoma tissue determined by RT-PCR. Data are presented as box-and-whisker plots, numbers of analyzed animals/treatment group are given below (n).