. 2022 Mar 23;23(7):3483. doi: 10.3390/ijms23073483

Table 2.

Modulation of hPTMs in HNSCC compared to normal tissues and in HPV+ HNSCC or E6/E7 transduced cells compared respectively to HPV− HNSCC or to “Cellular Control” (empty-vector transduced cells). ↑: upregulation; ↓: downregulation; –: control considered for the described sample comparison. ¹ and ² are used to indicate the samples considered when two options are reported in the column title. The technical approach (“Method”) through which the hPTMs have been detected is also reported.

hPTM	Normal Tissues ¹ or Cellular Control ²	HPV+ HNSCC Tissues ¹ or E6-E7 Transduced Cells ²	HPV− HNSCC Tissues	HNSCC Tissues (No Mention of HPV Status)	Method	Refs.
H3K27me3	– ²	↓ ²			Western Blot	[55]
//		↑ ¹	–		IHC	[54]
//	– ¹			↓	Mass Spectrometry	[53]
H3K327me3/K36me1	– ¹			↓	Mass Spectrometry	[53]
H3K327me2/K36me1	– ¹			↓	Mass Spectrometry	[53]
H3K327me1/K36me1	– ¹			↑	Mass Spectrometry	[53]
H3K327me1/K36me2	– ¹			↑	Mass Spectrometry	[53]
H3K36me2	– ¹			↑	Mass Spectrometry	[53]
//	– ¹			↑	IHC	[60]
//		– ¹	No differences		IHC	[60]
H3K36me1	– ¹			↑	Mass Spectrometry	[53]
H3K14ac	– ¹			↓	Mass Spectrometry	[53]
H4K20me1		↑ ¹	–		IHC	[54]
H4K20me3		↓ ¹	–		IHC	[54]