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. 2022 Mar 30;23(7):3832. doi: 10.3390/ijms23073832

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gut metabolomic profiling. (A) Heatmap showing the significantly changed metabolites of individuals in Crocetin-L group compared with DSS group. (B) PLS-DA scores plot revealed a clear separation of gut metabolites between the Crocetin-L and DSS groups. (C) Volcano plots of differential metabolites between Crocetin-L and DSS groups, red dots represent significantly up-regulated metabolites, blue dots represent significantly down-regulated metabolites, and grey dots represent metabolites with no significant change. (D) KEGG enriched pathways of differential gut metabolites in Crocetin-L group compared with DSS group. (E) Correlation of gut metabolites and microbiota between the Crocetin-L and DSS group. (F) Correlation network of differential metabolites and microbiota between the Crocetin-L and DSS group.