Figure 8.

Fenugreek supplementation improves cholesterol levels and high-density lipoprotein (HDL) balance in HF diet-fed mice. Whole blood was collected from fasted mice following 14 weeks on CD, CDFG, HF, or HFFG diet, and serum was separated and analyzed for total cholesterol, HDL, and low-density lipoprotein (LDL). (A,B) HDL and LDL are represented as percent cholesterol; (C–E) show the absolute levels of total cholesterol, HDL, and LDL. Results are presented as mean ± SEM for each group—CD, HF and HFFG (n = 11); CDFG (n = 7). Statistical significance was determined using Tukey’s multiple comparison test following a one-way ANOVA. Significance is represented as * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 for comparisons against the CD group. No significance (p < 0.05) was determined between the dietary groups and the respective FG supplemented group.