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. 2022 Mar 26;23(7):3649. doi: 10.3390/ijms23073649

Figure 4.

Figure 4

The common and specific core signaling pathways between COVID-19-associated ARDS and non-viral ARDS. This figure summarizes the genetic and epigenetic progression mechanism of COVID-19-associated ARDS and non-viral ARDS. The blue color background covers specific signaling pathways in non-viral ARDS. Overlapping core signaling pathways of COVID-19-associated ARDS and non-viral ARDS, namely common core signaling pathways, are covered in pink background. The skin color background covers specific signaling pathways in COVID-19-associated ARDS. The arrowheads in circle shapes indicate downregulation. The arrowheads in triangular shapes indicate upregulation. The solid lines indicate protein–protein interaction. The green nodes indicate high expression of protein/gene. The red nodes indicate low expression of protein/gene.