. 2022 Mar 26;23(7):3649. doi: 10.3390/ijms23073649

Table 3.

Comparison of numbers of edges in candidate HPI-GWGEN, real HPI-GWGEN of COVID-19-associated ARDS, and real HPI-GWGEN of non-viral ARDS after system identification.

Edges	Candidate HPI-GWGEN		Real HPI-GWGEN (Non-Viral ARDS)		Real HPI-GWGEN (COVID-19-Associated ARDS)
Edges	HPI-PPI	HPI-GRN	HPI-PPI	HPI-GRN	HPI-PPI	HPI-GRN
Proteins _↔ Proteins	3,013,811	222,665	1,400,482	128,900	1,445,193	124,144
Proteins _↔ Rcp	828,208	48,644	360,024	26,382	375,835	25,551
Proteins _↔ TF	455,807	20,823	219,681	12,044	234,620	11,616
Proteins _↔ RcpTF	21,098	2763	12,461	1642	12,905	1673
Proteins _↔ miRNA	0	34,039	0	9094	0	8458
Proteins _↔ LncRNA	0	60,640	0	28,705	0	27,298
Proteins _↔ Virus	200,475	236,925	0	0	117,139	1999
Rcp _↔ Rcp	56,203	1088	22,761	520	24,157	491
Rcp _↔ TF	62,965	537	28,875	267	31,100	247
Rcp _↔ RcpTF	2977	73	1679	38	1766	35
Rcp _↔ miRNA	0	2585	0	404	0	365
Rcp _↔ LncRNA	0	3559	0	1256	0	1265
Rcp _↔ Virus	27,500	32,500	0	0	14,958	306
TF _↔ TF	15,427	18	7983	11	8893	12
TF _↔ RcpTF	1677	9	1093	5	1229	7
TF _↔ miRNA	0	1218	0	164	0	197
TF _↔ LncRNA	0	1476	0	546	0	629
TF _↔ Virus	16,709	19,747	0	0	10,003	203
RcpTF _↔ RcpTF	9	1	6	1	6	1
RcpTF _↔ miRNA	0	132	0	14	0	20
RcpTF _↔ LncRNA	0	145	0	50	0	58
RcpTF _↔ Virus	1155	1365	0	0	750	14
miRNA _↔ miRNA	0	1039	0	36	0	36
miRNA_↔ LncRNA	0	3340	0	803	0	586
miRNA _↔ Virus	0	17,914	0	0	0	28
LncRNA _↔ LncRNA	0	2633	0	1139	0	1109
LncRNA _↔ Virus	0	36,192	0	0	0	383
Virus _↔ Virus	66	91	0	0	4	0
Total (PPI/GRN)	4,704,087	752,161	2,055,045	212,021	2,278,558	206,762
Total (PPI+GRN)	5,456,248		2,267,066		2,485,320

NOTE: Edges are defined as interactions between 2 nodes and expressed with” node1 ↔ node2”, where “node1” and “node2” are gene/protein names from one of the 7 classes we defined.