Figure 2.

Example of a metastatic pancreatic ductal adenocarcinoma patient under distinct chemotherapy regimens (gemcitabine/nab-paclitaxel followed by modified FOLFIRINOX). (a) Early ⁶⁸Ga-FAPI PET images 10 min p.i. (b) Late ⁶⁸Ga-FAPI PET images 60 min p.i. Clockwise from upper-left: PET/CT fusion anterior view, PET/CT fusion lateral view, PET maximum-intensity-projection anterior view. Hybrid imaging shows the primary pancreatic carcinoma, multiple liver metastases, and peritoneal nodules (indicative of peritoneal carcinomatosis), each with intense FAP-expression. Chemotherapy-related cardiotoxicity was suspected due to increased cardiac FAP-expression (emphasized in early images p.i.) and incomplete cardiac wash-out (observed in late images). PET/CT images were acquired at our institution.