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. 2022 Mar 31;23(7):3894. doi: 10.3390/ijms23073894

Figure 2.

Figure 2

The cerebellar circuit. Schematic representation of the main components of the cerebellar circuit. The inputs are provided by mossy fibers (MF) and climbing fibers (CF), these latter originating in the inferior olive (IO). Both inputs send collaterals to the deep cerebellar nuclei (DCN) before entering the cerebellar cortex. Granule cells (GrC) and Golgi cells (GoC) are the main neuronal types present in the granular layer (GL) of the cerebellar cortex. GrC axons reach the molecular layer (ML) where they bifurcate originating the parallel fibers (PF). The inhibitory interneurons in the ML are stellate cells (SC) and basket cells (BC), which inhibit Purkinje cells (PC) in the Purkinje cell layer (PCL). The PC provides the output of the cerebellar cortex, inhibiting DCN neurons, which in turn provide the main output of the cerebellar circuit. Notice that DCN project to the IO, generating a loop mediated by the CF.