Cerebellar connectivity to other brain areas. The cerebellum is one of the most interconnected structures in the brain. (A) Schematic representation of the mouse brain and the main cerebellar connections thought to be relevant for its role in ASD. DCN, deep cerebellar nuclei; PN, pontine nuclei (including reticulo-tegmental nuclei and pedunculopontine nuclei); VTA, ventral tegmental area; am, amygdala; hip, hippocampus; VL, ventrolateral thalamic nucleus; MD, mediodorsal thalamic nucleus; M1, primary motor cortex; ACC, anterior cingulate cortex; mPFC, medial prefrontal cortex. (B) Same representation as in (A), showing the pathways involving the limbic system. (C) Same representation as in (A), showing the connections involved in the mesocortical dopaminergic pathways, regulating mPFC activity modulation.