Table 1.

This table summarizes the main abnormalities reported in the cerebellum in mouse models of ASD.

Mouse Model	Neurochemical Changes	Structural/Cellular Abnormalities	Functional Abnormalities	Behavioral Deficits
EN2-KO		■Foliation ■Hypoplasia ■↓ PC number	■Motor coordination ■Grip strength reflexes ■↑ Seizure susceptibility	■↓ Sociability ■↓ Spatial memory
RORα-KO (staggerer)		■↓ PC number ■↓ GrC number	■Ataxia
FOXP2-KO		■Hypoplasia ■PC migration ■PC maturation	■PC synaptic plasticity ■Motor learning	■↓ Vocalization
Reelin-mutant (reeler)		■Hypoplasia ■PC positioning ■↓ GrC number	■Ataxia
MET-mutant		■Foliation ■Hypoplasia ■↓ GrC proliferation	■Balance control ■Complex movements
PTEN-KO (cerebellum)	■↑ Kv4.2 ■↑ NR2A subunit ■↑ mGluR1/5	■Hypertrophy ■↑ GrC soma size	■Motor coordination ■↑ Seizure susceptibility
PTEN-KO (Purkinje cell)		■Enlarged soma ■Thicker axons and dendrites	■↓ PC firing rate ■↓ EPSC amplitude (PF-PC synapse)	■↓ Sociability ■Repetitive behavior
CAPDS2-KO		■Vermis hypoplasia ■↑ GrC apoptosis ■↓ PC number ■Aberrant PC arborization ■Enlarged PF terminal boutons	■↓ PPF at PF-PC synapse	■↓ Sociability ■Hyperactivity ■↓ Exploratory behavior ■↑Anxiety
GABRB3-KO		■Vermis hypoplasia	■Motor coordination	■↓ Sociability ■Hyperactivity ■↓ Exploratory behavior
FMR1-KO		■Hypoplasia ■↓ DCN cell number ■Enlogated PC spines	■↓ Eye-blink conditioning ■↑ LTD at PF-PC synapse ■↓ cerebellar-induced dopamine release on mPFC	■Repetitive behavior ■Hyperactivity
MeCP2-KO	■↓ BDNF	■Hypoplasia ■↓GrC soma size ■↑ densely packed GrC	■Motor learning ■Irregular PC firing	↓
TSC1-KO TSC2-KO (Purkinje cell)		■↓ PC number ■Abnormal PC spine density	■↓ Eye-blink conditioning ■↓ PC firing rate ■Ataxia	■↓ Sociability ■Repetitive behavior
UBE3A-KO	■GAT1 upregulation		■Motor coordination ■Balance control ■↑ PC firing rate ■Ataxia
patDp/+		■Multiple innervation of PCs by CFs	■Motor coordination ■↓ Eye-blink conditioning	■↓ Sociability ■↓ Vocalization ■Behavioral inflexibility
SHANK1-KO			■Motor coordination ■Balance control	■Repetitive behavior ■↓ Vocalization
SHANK2 e6/7-KO			■Motor coordination	■↓ Sociability ■Repetitive behavior ■↓ Vocalization ■Hyperactivity
SHANK2 e7-KO			■↓ LTD at PF-PC synapse ■Irregular PC firing ■↑ Inhibition inputs onto PCs
SHANK2-KO (L7 Purkinje cell)				■↓ Sociability ■Repetitive behavior ■↓ Vocalization ■Hyperactivity
SHANK2-KO (Pcp2 Purkinje cell)			■Motor coordination
SHANK3-ΔC		■↓ PC number ■↓ PC spine density	■Motor coordination ■Motor learning	■↓ Sociability ■Repetitive behavior ■Novelty avoidance
NLGN3-KO			■Motor coordination ■↓ LTD at PF-PC synapse	■↓ Sociability ■Repetitive behavior
NLGN3-R451C	■↓ NLGN3 protein exporession		■↑ mIPSC frequency ■↓ Ca2+ transient induced by CF inputs ■Multiple innervation of PCs by CFs	■↓ Sociability ■Repetitive behavior
IB2-KO		■Thinner PC dendrites ■Shorter PC dendritic arbor	■Motor learning ■↑ GrC excitability ■↑ NMDA-EPSC ■Deregulation of voltage-gated Na+ and K+- currents ■Alteration in E/I balance ■↑ LTP at MF-GrC synapse	■↓ Sociability ■↓ Exploratory behavior